Have you ever wondered which weight loss remedy Is Tirzepatide versus Semaglutide better for you? Have you wanted to understand how these products work and which one produces better results? If so, this article is for you! In it, we address the following questions what is Semaglutide, how it differs from thirzepatide and what effects they have on the body. You will learn why Tirzepatide is worth using and what advantages it has over Semaglutide. Are you ready to get rid of excess fat and enjoy your body? If not yet, this article should convince you.
What is thirzepatide?
Thirzepatide is a completely new peptide that has been approved by the European Medicines Agency. Thirzepatide is a medication administered once a week via an injector that helps lower blood sugar levels and promote weight loss. The peptide has shown efficacy in lowering blood sugar levels in patients with type 2 diabetes (but not only), both as monotherapy and in combination with other anti-diabetic drugs such as metformin, sulfonylurea or insulin. Thioparatide also helps reduce the risk of cardiovascular complications, such as heart attack or stroke, by improving risk factors such as blood pressure, cholesterol and inflammation. Thiothiopatide also has a beneficial effect on patients' quality of life, as it improves their mood and reduces symptoms of depression.
How does thirzepatide work?
Thirzepatide mimics the action of our body's natural hormones, increasing insulin production and slowing gastric emptying. Importantly, This helps keep blood sugar levels stable, which in turn can help control appetite. Thiopeptide is a peptide in the GLP-1 receptor agonist group, a group of hormones that stimulate insulin secretion by the pancreas and inhibit glucagon secretion by the liver. Glucagon is a hormone that raises blood sugar levels. Thirzepatide mimics the action of natural GLP-1, but is more durable and potent. Thirzepatide also has an additional mechanism of action, as it binds to GIP receptors, another hormone associated with glucose metabolism. This gives thirzepatide a better effect on glycemic control and weight reduction than other drugs in this group.
Slimming properties of Tirzepatide
Thirzepatide can help with weight loss by increasing the feeling of satiety, which in turn leads to lower caloric intake. Thirzepatide may help in the fight against obesity. It is a synthetic analog of glucagon-like peptide-1 (GLP-1), which stimulates insulin secretion and suppresses appetite. Thirzepatide has several advantages over other drugs in this group, such as liraglutide or semaglutide. In this article, we will review the weight-loss properties of thirzepatide and its potential health benefits.
It works in two ways: it improves glycemic control and reduces body weight. According to clinical trials, thiothiazepatide can lower blood sugar levels by about 2% and reduce body weight by about 12% in a year. This is significantly more than other drugs in the same class that produce a weight-loss effect of 4-6%.
How is it possible that tirzepatide is so effective? Well, tirzepatide mimics the action of the natural hormone GLP-1, which is secreted by the gut after a meal. GLP-1 signals the brain that we are full and reduces feelings of hunger. In addition, GLP-1 stimulates the pancreas to produce insulin, which helps transport glucose into cells and lowers blood sugar levels. However, thiopeptide has a longer duration of action than GLP-1 because it is resistant to breakdown by digestive enzymes. The peptide also has a higher affinity for GLP-1 receptors than other drugs in the group, meaning it is more potent in its activity.
Thioparatide not only helps people lose weight, but also improves the health of people with obesity and type 2 diabetes. Obesity and diabetes are risk factors for a number of serious diseases, such as heart disease, stroke, kidney failure and eye disorders. Thiothiazepatide can prevent or delay the onset of these complications by improving metabolic parameters such as blood pressure, cholesterol and inflammation. It can also have a beneficial effect on patients' quality of life, improving their mood, well-being and sexual functioning.
Thirzepatide is a promising agent for people with obesity and type 2 diabetes that can significantly improve their weight loss results and health. It is safe and well tolerated, although it may cause some side effects such as nausea, vomiting, diarrhea and abdominal pain. For best results, use thirzepatide in conjunction with a low-calorie diet and physical activity.
What is Semaglutide?
Semaglutide is an agent used in the treatment of type 2 diabetes, which also has a weight-loss effect. It is a synthetic analog of the human hormone GLP-1, which stimulates insulin secretion and inhibits glucagon secretion. Semaglutide (like tirzepatide) is administered once a week using a subcutaneous injector.
It has many benefits, such as:
- Lowering blood sugar and glycated hemoglobin (HbA1c) levels
- Reduction of body weight and waist circumference
- Improve blood pressure and lipid profile
- Reduce the risk of cardiovascular and renal complications
The agent may cause some side effects, such as:
- Nausea, vomiting, diarrhea and constipation
- Abdominal pain and heartburn
- Hypoglycemia (low blood sugar)
- Allergic reactions and pancreatitis (rare)
Semaglutide is available under the trade name Ozempic.
How does Semaglutide work?
Like Thirzepatide, Semaglutide mimics the body's natural hormones, increasing insulin production and delaying gastric emptying. Semaglutide works in several ways:
- It increases the production of insulin by the beta cells of the pancreas, which facilitates the transport of sugar from the blood into the cells.
- It inhibits the secretion of glucagon by the alpha cells of the pancreas, which prevents blood sugar levels from rising after a meal.
- It slows gastric emptying, which reduces appetite and the amount of food consumed.
- It improves liver function, which reduces the production of glucose from glycogen.
The dose of semaglutide is selected individually, starting at 0.25 mg per week and gradually increasing to a maximum of 1 mg per week.
Weight loss properties of Semaglutide
Semaglutide can help control appetite, leading to a reduction in caloric intake and potential weight loss. GLP-1 also affects the hunger and satiety center in the brain, reducing appetite and increasing feelings of fullness after a meal. As mentioned earlier, semaglutide is administered once a week using a subcutaneous injector. The dose of the drug should be gradually increased to reduce the risk of side effects, such as nausea, vomiting, diarrhea or constipation. The drug can be used alone or in combination with other anti-diabetic drugs.
Clinical studies have shown that semaglutide is effective in both lowering blood sugar levels and reducing body weight. In one study patients Those receiving semaglutide for 68 weeks lost an average of 14.9% of body weight, while patients receiving placebo lost only 2.4%. In addition, semaglutide improved patients' lipid parameters, blood pressure and quality of life.
Semaglutide is a safe drug and well tolerated by most patients. However, some people may experience gastrointestinal side effects or allergic reactions at the injection site. The drug is not recommended for pregnant or breastfeeding women, people with pancreatic or thyroid disease, or those with severe kidney or liver disorders.
Comparison of Thirzepatide vs Semaglutide
Thirzepatide versus semaglutide are two agents that are effective for weight loss. Both substances belong to the group of agonists of the GLP-1 receptor, the hormone that stimulates insulin secretion. However, it should be noted that thioglutide also acts on GIP receptors, which are responsible for glucose metabolism. Below is presented a chart where the weight-loss effects of the two peptides are compared.
Effectiveness
Thiothiazepatide versus semaglutide - show similar efficacy in lowering blood glucose levels and glycated hemoglobin (HbA1c), an indicator of average glucose levels over the past 3 months. According to clinical trials, both substances can reduce HbA1c by about 2% compared to placebo. In addition, both thiothiazepatide and semaglutide can help reduce body weight, which is beneficial for overweight or obese patients. The average weight loss after 40 weeks of treatment was about 10 kg for tirzepatide and about 7 kg for semaglutide. The effect of tirzapetide in terms of weight loss is therefore much more effective.
Security
Thiothiazepatide versus semaglutide - are generally well tolerated by patients, but can cause some side effects. The most common are nausea, vomiting, diarrhea and abdominal pain, which usually resolve after a few weeks of treatment. Less commonly, hypoglycemia (low blood sugar), pancreatitis, thyroid dysfunction or allergic reactions may occur. Thiothiazepatide and semaglutide are not recommended for pregnant or breastfeeding women, people with kidney or liver failure, or those with a history of neuroendocrine tumors. However, it should be noted that users of thiothrombotide indicate less frequent adverse effects.
Method of administration
Thirzepatide and semaglutide are available as subcutaneous injections that patients can administer themselves. Both substances can be administered once a week. Both peptides can be combined with other diabetes medications, such as metformin, sulfonylureas or SGLT2 inhibitors. It is important to follow the doctor's instructions and monitor blood glucose levels during treatment.
Which is better: thirzepatide versus Semaglutide?
If you want to improve the appearance of your figure and get rid of excessive fat, then definitely bet on Thirzepatide. Weight loss with thirzepatide is more effective. Scientific studies confirm that the peptide brings excellent results in reducing body fat, and even without taking additional activity. What's more, thiothiazepatide also improves other parameters of your health. In addition to its weight-loss properties, it will also take care of your heart and circulatory system.
Thirzepatide versus semaglutide - summary
A comparison of the two substances indicates that Thirzepatide is more effective in lowering blood sugar and weight loss compared to Semaglutide. Both peptides act on GLP-1 receptors, but Thirzepatide additionally affects GIP receptors, resulting in better weight loss results. Depending on the individual patient's needs, the choice between the two products will depend on preference and an assessment of benefits and side effects. Thiogepatide, as well as Semaglutide, can benefit people with overweight and type 2 diabetes, but Thiogepatide appears to have an advantage in terms of weight loss effects.
Sources:
https://www.nejm.org/doi/full/10.1056/NEJMoa2206038
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987449/
https://pubmed.ncbi.nlm.nih.gov/36507900/
https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.15148
https://www.biochempeg.com/article/355.html
