BAM-15 25 mg 60 caps

BAM-15 - what it is and how it works

BAM-15 is an experimental chemical compound belonging to the class of mitochondrial uncouplers of oxidative phosphorylation (mitochondrial uncouplers). Its mechanism of action is to selectively increase the permeability of the inner mitochondrial membrane to protons, leading to a decoupling of the electron transport process from ATP synthesis. In practice, this means that some of the chemical energy, instead of being stored in ATP, is dissipated as heat, resulting in a increased energy expenditure at the cellular level.

Unlike historical mitochondrial uncouplers such as dinitrophenol (DNP), BAM15 is designed to not cause an uncontrolled rise in body temperature. Preclinical studies indicate that BAM-15 acts selectively on mitochondria, increasing the rate of oxidation of energy substrates, particularly fatty acids, without interfering with basic cellular functions in the models tested.

BAM-15 - is it a peptide ?

BAM-15 is not a peptide. It is low-molecular-weight chemical compound, designed as a synthetic modulator of mitochondrial function. Unlike peptides, which are composed of amino acids and often exhibit limited oral bioavailability, BAM15 belongs to a group of non-peptide organic molecules, which is only relevant in the context of its laboratory studies and mechanism of action. This classification distinguishes BAM15 from many metabolic compounds based on peptide structures that have been studied.

BAM-15 metabolic effects in preclinical studies

In preclinical studies, including those published in the Nature Communications and EMBO Molecular Medicine, it has been shown that BAM15 can reverse diet-related metabolic disorders In animal models. The relationship led to reduce weight gain, improving lipid profile and increase insulin sensitivity, even without significant changes in the caloric supply or physical activity of the animals.

In models of obesity induced by a high-fat diet, it was observed that BAM15 improved the glycemic control, reduced hepatic steatosis, and had beneficial effects on metabolic parameters associated with metabolic syndrome. These mechanisms were directly related to increased energy consumption at the mitochondrial level and enhanced fatty acid oxidation.

BAM-15 - dosage

BAM15 is located Only at the stage of preclinical studies. All available data are from in vitro and animal model studies. No human clinical trials have been conducted, and dosage information is limited to experimental protocols used in animal studies.

Doses of BAM15 were adjusted according to the weight of the animals and the specific metabolic model. For this reason there is no approved or proposed therapeutic dosage, and any dose figures cannot be related to potential use in humans.

BAM15 - where to buy ?

BAM-15 is not approved for marketing as a medicinal product or dietary supplement and is not available in pharmacies. The substance can only be offered as Research reagent for scientific research and laboratory analysis, available from selected research & development suppliers.

BAM15 - side effects and safety

The safety profile of BAM-15 in humans has not been determined. Although preclinical studies suggest that the compound does not cause acute toxicity or uncontrolled increases in body temperature in the models studied, the authors of the publication emphasize the need for caution in interpreting the results.

Scientific reviews, including those published in Frontiers in Endocrinology, point out that Mitochondrial uncoupling of oxidative phosphorylation as a therapeutic strategy poses significant safety challenges, especially in the context of long-term use. Comments in the journal Diabetes indicate that current research tends to focus on the development of the safer derivatives and precise modulators of this mechanism, than on the direct use of BAM15 as a potential drug.

BAM15 - price and market availability

BAM15 has no pharmacy price or medicinal product status. The substance may be available only as a research reagent for scientific and experimental research, offered to laboratories and research institutions. It is not intended for use in humans or for therapeutic purposes.

Information sources:

Nature Communications (2020)
BAM15 reverses diet-related metabolic disorders; mechanism of action and tolerance in animal models.
https://www.nature.com/articles/s41467-020-16298-2

PubMed
Abstract and metadata of the Nature Communications publication on BAM15.
https://pubmed.ncbi.nlm.nih.gov/32409697/

EMBO Molecular Medicine (2020)
Research on obesity protection and improved glycemic control in preclinical models.
https://link.springer.com/article/10.15252/emmm.202012088

Frontiers in Endocrinology (2023)
Review of the mechanism of BAM15 as a mitochondrial uncoupler and discussion of the limitations of this strategy.
https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1252141/epub

Diabetes (2024)
Commentary on the risks and directions for developing safer derivatives of mitochondrial uncoupling strategies.
https://diabetesjournals.org/diabetes/article-lookup/doi/10.2337/dbi23-0033