5-Amino-1MQ 50 mg 30 caps

5-Amino-1MQ - what is it and how does it work?

5-Amino-1MQ (often described as 5-amino-1-methylquinolinium) is a small-molecule inhibitor of the enzyme NNMT (nicotinamide N-methyltransferase), which is involved in nicotinamide metabolism and affects the balance of pathways related to NAD⁺ and methylation metabolism (SAM/SAH). In cellular and animal models, inhibition of NNMT has been linked to favorable metabolic changes in adipose tissue and muscle, which has formed the basis for interest in this axis as a potential research direction for obesity and metabolic disorders.

5-Amino-1MQ - effects related to body weight and metabolism (research papers)

In a paper describing selective, membrane-penetrating NNMT inhibitors, it was shown that inhibition of NNMT by 5-amino-1MQ in a model of diet-related obesity was associated with weight loss and fat mass reduction. In parallel, effects on NAD⁺/nicotinamide-related metabolites and methylation have been discussed, supporting a mechanistic link between NNMT and energy metabolism. Reviews on NNMT in obesity point in this direction as promising research, but still requiring clinical confirmation.

5-Amino-1MQ dosage regimens according to available sources

5-Amino-1MQ has no approved dosage for humans and is not a registered drug for the treatment of obesity. Administration data are from preclinical studies where the effects of the NNMT inhibitor on body weight, adipose tissue and selected metabolic markers were evaluated in animals on a high-fat diet. The publications describe in vivo protocols (DIO models), but do not provide a basis for inferring doses in humans or making supplementation/therapeutic recommendations.

5-Amino-1MQ - side effects and safety

Since clinical studies in humans are lacking, the safety profile of 5-amino-1MQ in therapeutic use is not established. The literature emphasizes that modulation of the NNMT-NAD⁺-methylation axis is a biologically „profound” metabolic intervention, so assessment of long-term safety requires a full pathway of clinical studies (pharmacokinetics, interactions, organ side effects).

5-Amino-1MQ - market price and availability

5-Amino-1MQ is sometimes offered as a reagent for laboratory work, while it does not function as a drug product available in pharmacies. If you're describing availability in SEO, it's clearest (and safest) to communicate that it's a substance used in metabolism and NNMT research, without suggesting therapeutic uses in humans.

5-Amino-1MQ - where to buy?

In clinical and therapeutic terms, 5-Amino-1MQ is not „for sale” as a drug, as there is no pharmacy registration for the treatment of obesity. The real-world, legal context applies only to research applications (scientific institutions/laboratories) or future clinical trials, if any are launched.

Sources:

1. PMC - Neelakantan et al (full text): selective NNMT inhibitors, mechanism, in vitro and in vivo data (DIO mice), effects on fat mass/tissue: https://pmc.ncbi.nlm.nih.gov/articles/PMC5826726/

2. SciDirect - journal version / linked bibliographic record: NNMT inhibition and effects in DIO mice: https://www.sciencedirect.com/science/article/am/pii/S0006295217306718

3. Review (2021) on NNMT in obesity - biological context and mention of 5-amino-1MQ: https://pmc.ncbi.nlm.nih.gov/articles/PMC8337113

4. Nature / Scientific Reports (2022) - NNMT inhibition + diet, additional metabolic context (microbiome/DIO model): https://www.nature.com/articles/s41598-021-03670-5