5-Amino-1MQ is a novel molecule linked to the regulation of energy metabolism. In studies, it is analyzed for its effect on energy utilization and reducing fat storage.
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5-Amino-1MQ, also known as 5-amino-1-methylquinolinium, is a small-molecule experimental compound belonging to the class of selective enzyme inhibitors NNMT – nicotinamide N-methyltransferase. This enzyme is involved in nicotinamide metabolism and influences pathways related to NAD⁺ availability, energy metabolism, and methylation processes dependent on the SAM/SAH system.
Interest in the compound 5-Amino-1MQ stems primarily from its ability to inhibit NNMT activity, which has been observed to be elevated in certain metabolic tissues, including adipose tissue. Preclinical studies have examined the relationships between the activity of this enzyme and energy storage, adipocyte function, nicotinamide metabolism, and the regulation of processes occurring in adipose and muscle tissue.
5-Amino-1MQ is a non-peptide compound, which means it does not have the amino acid sequence characteristic of research peptides. Its small-molecule structure and ability to penetrate cell membranes make it suitable for use in analyses of intracellular NNMT activity, NAD⁺-dependent pathways, and metabolic processes related to energy balance.
In the scientific literature, 5-Amino-1MQ is described as a selective NNMT inhibitor of experimental significance, used in cellular and animal models. This compound is used, among other things, in research on the biological role of NNMT, adipose tissue function, energy metabolism, and the relationships between nicotinamide, NAD⁺, and methylation processes.
The high purity of the material allows 5-Amino-1MQ to be used in qualitative analyses, comparative studies, and reference procedures conducted under laboratory conditions. The product is intended for scientific research, laboratory analyses, and reference applications.
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5-Amino-1MQ has attracted the interest of the scientific community due to its effect on NNMT enzyme activity and the potential to analyze its role in the regulation of metabolic processes. Preclinical studies evaluated how NNMT inhibition affects cellular metabolism, adipose tissue function, the utilization of energy substrates, and nicotinamide metabolism.
One of the most frequently cited studies on 5-Amino-1MQ described selective NNMT inhibitors capable of crossing the cell membrane. In a diet-induced obesity model, the compound’s effect on body weight, body fat content, and selected metabolic parameters was analyzed. The results indicated that inhibition of NNMT activity was associated with changes in adipose tissue metabolism and energy balance.
The researchers also analyzed the effect of 5-Amino-1MQ on the concentrations of nicotinamide-related metabolites, NAD⁺, and methylation reactions. NNMT catalyzes the conversion of nicotinamide using S-adenosylmethionine; therefore, its activity can affect both the availability of NAD⁺ precursors and the balance of the SAM/SAH system. This mechanism is one of the main areas of research into the biological significance of NNMT inhibition.
In cellular and animal models, the relationships between NNMT activity and adipocyte function, lipid storage, energy expenditure, and the metabolic response to a high-fat diet were also evaluated. For this reason, 5-Amino-1MQ is used as a research compound in projects related to adipose tissue biology, cellular metabolism, and the mechanisms regulating energy homeostasis.
Scientific reviews on NNMT indicate that this enzyme may play a significant role in regulating metabolism and the function of metabolically active tissues. At the same time, the available data on 5-Amino-1MQ come primarily from preclinical studies; therefore, the compound remains an experimental tool used to analyze the mechanism of NNMT, rather than an approved medicinal product.
Growing interest in the axis NNMT–nicotinamide–NAD⁺ This has led to 5-Amino-1MQ being increasingly analyzed as a small-molecule reference inhibitor. It serves as a valuable tool for research into energy metabolism, lipid metabolism, the regulation of adipocyte activity, and the impact of methylation processes on cellular function.
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INTENDED FOR RESEARCH PURPOSES!
All properties mentioned above are observed with laboratory tests, not done on humans, and are for informational purposes only. Any information contained in the descriptions has not been approved by GIS, GIF or EFSA. The substance is not a drug, food product or dietary supplement, consequently it is not suitable for human consumption. The product qualifies as a chemical reagent / reference material approved for marketing in the EU. It can only be used for scientific research. For other information on the agent, please refer to the Material Safety Data Sheet, which is available for review. The products are available only to institutions or individuals who are associated with research or laboratory activities.
5-Amino-1MQ 50 mg 30 caps
| 5 gwiazdek | 86% | |
| 4 gwiazdki | 10% | |
| 3 gwiazdki | 3% | |
| 2 gwiazdki | 1% | |
| 1 gwiazdka | 0% |
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