{"id":35587,"date":"2026-05-21T14:08:15","date_gmt":"2026-05-21T12:08:15","guid":{"rendered":"https:\/\/tirzepatyd.eu\/?post_type=product&p=35587"},"modified":"2026-06-19T16:56:57","modified_gmt":"2026-06-19T14:56:57","slug":"orforglipron-10-mg","status":"publish","type":"product","link":"https:\/\/tirzepatyd.eu\/cs\/obchod-produkt\/orforglipron-10-mg\/","title":{"rendered":"GLP-1 Orforglipron 10 mg 60 kapsl\u00ed"},"content":{"rendered":"
\n\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Orforglipron 10 mg \u2013 charakteristika p\u0159\u00edpravku<\/h2>

Orforglipron 10 mg<\/strong> Jedn\u00e1 se o nepeptidovou experiment\u00e1ln\u00ed slou\u010deninu za\u0159azenou mezi agonisty receptoru GLP-1 (GLP-1R), kter\u00e1 je v odborn\u00e9 literatu\u0159e uv\u00e1d\u011bna tak\u00e9 pod ozna\u010den\u00edm LY3502970. Na rozd\u00edl od klasick\u00fdch analog\u016f GLP-1 zalo\u017een\u00fdch na peptidov\u00e9 struktu\u0159e je orforglipron syntetick\u00fdm n\u00edzkomolekul\u00e1rn\u00edm ligandem, co\u017e z n\u011bj \u010din\u00ed zaj\u00edmav\u00fd objekt v\u00fdzkumu inkretinov\u00e9 signalizace, receptor\u016f spojen\u00fdch s G-proteinem (GPCR) a vlastnostmi nepeptidov\u00fdch agonist\u016f GLP-1R.<\/p>

Orforglipron m\u00e1 sum\u00e1rn\u00ed vzorec C\u2084\u2088H\u2084\u2088F\u2082N\u2081\u2080O\u2085, molekulovou hmotnost 882,96 g\/mol a \u010d\u00edslo CAS 2212020-52-3. Jako nepeptidov\u00e1 slou\u010denina nem\u00e1 aminokyselinovou sekvenci charakteristickou pro studovan\u00e9 peptidy. Ve v\u011bdeck\u00fdch publikac\u00edch upout\u00e1v\u00e1 pozornost p\u0159edev\u0161\u00edm svou chemickou stabilitou, schopnost\u00ed interagovat s receptorem GLP-1R bez vyu\u017eit\u00ed peptidov\u00e9 struktury a vysokou selektivitou v\u016f\u010di zkouman\u00e9mu molekul\u00e1rn\u00edmu c\u00edli. Deklarovan\u00e1 \u010distota produktu \u010din\u00ed \u226599% HPLC, co\u017e umo\u017e\u0148uje pou\u017eit\u00ed tohoto materi\u00e1lu v kvalitativn\u00edch anal\u00fdz\u00e1ch, srovn\u00e1vac\u00edch studi\u00edch a referen\u010dn\u00edch postupech.<\/p>

V\u00fdzkum orforglipronu<\/h3>

Orforglipron vzbudil zna\u010dn\u00fd z\u00e1jem v\u011bdeck\u00e9 obce d\u00edky sv\u00e9 aktivit\u011b v\u016f\u010di receptoru GLP-1R a v\u00fdzkumn\u00e9mu potenci\u00e1lu v oblasti regulace metabolismu a energetick\u00e9 bilance. V publikovan\u00fdch studi\u00edch byl analyzov\u00e1n jeho vliv na sign\u00e1ln\u00ed dr\u00e1hy souvisej\u00edc\u00ed s metabolismem gluk\u00f3zy, regulac\u00ed chuti k j\u00eddlu a mechanismy pod\u00edlej\u00edc\u00edmi se na udr\u017eov\u00e1n\u00ed t\u011blesn\u00e9 hmotnosti.<\/p>

V odborn\u00e9 literatu\u0159e je orforglipron popisov\u00e1n jako jeden z nejpokro\u010dilej\u0161\u00edch nepeptidov\u00fdch agonist\u016f GLP-1R, d\u00edky \u010demu\u017e se stal p\u0159edm\u011btem \u010detn\u00fdch studi\u00ed zam\u011b\u0159en\u00fdch na metabolick\u00e9 procesy a fyziologii inkretinov\u00e9ho syst\u00e9mu. P\u0159edklinick\u00e9 a klinick\u00e9 anal\u00fdzy prok\u00e1zaly aktivaci biologick\u00fdch drah charakteristick\u00fdch pro receptory GLP-1, d\u00edky \u010demu\u017e je tato slou\u010denina \u0161iroce vyu\u017e\u00edv\u00e1na jako referen\u010dn\u00ed materi\u00e1l ve v\u00fdzkumn\u00fdch projektech t\u00fdkaj\u00edc\u00edch se metabolismu, energetick\u00e9 homeost\u00e1zy a regulace p\u0159\u00edjmu potravy.<\/p>

D\u00edky rostouc\u00edmu po\u010dtu v\u011bdeck\u00fdch publikac\u00ed v\u011bnovan\u00fdch orforglipronu je tento p\u0159\u00edpravek v sou\u010dasnosti jedn\u00edm z nej\u010dast\u011bji analyzovan\u00fdch n\u00edzkomolekul\u00e1rn\u00edch agonist\u016f GLP-1R a p\u0159edstavuje cenn\u00fd n\u00e1stroj pro v\u00fdzkum mechanism\u016f reguluj\u00edc\u00edch t\u011blesnou hmotnost, inkretinovou signalizaci a fungov\u00e1n\u00ed receptor\u016f spojen\u00fdch s G-proteinem.<\/p>

\"Orforglipron<\/a><\/p>

V\u011bdeck\u00e9 zdroje:<\/strong><\/p>

  1. Kawai et al., PNAS<\/strong> - strukturn\u00ed studie popisuj\u00edc\u00ed mechanismus aktivace receptoru GLP-1 nepeptidov\u00fdm agonistou LY3502970 \/ orforglipronem a jeho profil \u010d\u00e1ste\u010dn\u00e9ho agonisty GLP-1R.<\/a><\/li>
  2. Pratt et al, Diabetes, obezita a metabolismus \/ PubMed<\/strong> - publikace o orforglipronu jako nov\u00e9m peror\u00e1ln\u00edm nepeptidov\u00e9m agonistovi receptoru GLP-1 analyzovan\u00e9m ve studii f\u00e1ze 2.<\/a><\/li>
  3. Wharton et al, New England Journal of Medicine<\/strong> - studie f\u00e1ze 2 popisuj\u00edc\u00ed orforglipron jako peror\u00e1ln\u00edho agonistu receptoru GLP-1 analyzovan\u00e1 u dosp\u011bl\u00fdch \u00fa\u010dastn\u00edk\u016f studie.<\/a><\/li>
  4. PubChem \/ ChEMBL<\/strong> - chemick\u00e9 datab\u00e1ze potvrzuj\u00edc\u00ed z\u00e1kladn\u00ed identifikaci slou\u010deniny, v\u010detn\u011b \u010d\u00edsla CAS, sum\u00e1rn\u00edho vzorce a molekulov\u00e9 hmotnosti orforgliprone<\/a><\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

    Orforglipron 10 mg<\/strong> je vysoce kvalitn\u00ed nepeptidov\u00e1 v\u00fdzkumn\u00e1 l\u00e1tka GLP-1 ve form\u011b kapsl\u00ed, vyvinut\u00e1 pro laboratorn\u00ed studie signalizace GLP-1R, inkretinov\u00fdch drah a metabolick\u00fdch mechanism\u016f. Pro v\u00fdzkumn\u00e9, analytick\u00e9 a referen\u010dn\u00ed pou\u017eit\u00ed.<\/p>","protected":false},"featured_media":35588,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[135,15],"product_tag":[],"class_list":["post-35587","product","type-product","status-publish","has-post-thumbnail","product_cat-produkty-w-kapsulkach","product_cat-laboratory-research","first","instock","sale","shipping-taxable","purchasable","product-type-simple"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t