{"id":20220,"date":"2024-08-03T21:58:03","date_gmt":"2024-08-03T19:58:03","guid":{"rendered":"https:\/\/tirzepatyd.eu\/?post_type=product&#038;p=20220"},"modified":"2026-05-03T21:42:48","modified_gmt":"2026-05-03T19:42:48","slug":"tirzepatide-pero-10-mg","status":"publish","type":"product","link":"https:\/\/tirzepatyd.eu\/cs\/obchod-produkt\/tirzepatide-pero-10-mg\/","title":{"rendered":"GLP1+GIP PEN 10 mg"},"content":{"rendered":"<div data-elementor-type=\"product-post\" data-elementor-id=\"20220\" class=\"elementor elementor-20220\" data-elementor-post-type=\"product\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-82c1bc5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"82c1bc5\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-edd1509\" data-id=\"edd1509\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7597d2d elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"7597d2d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<h2 data-start=\"66\" data-end=\"117\">Tirzepatid Pen 10 mg - charakteristiky<\/h2><p data-start=\"119\" data-end=\"376\"><strong data-start=\"119\" data-end=\"144\">Tirzepatid pero 10 mg<\/strong> odkazuje na formuli pou\u017eitou v klinick\u00fdch studi\u00edch syntetick\u00e9ho peptidov\u00e9ho analogu tirzepatide. Tato l\u00e1tka je du\u00e1ln\u00edm agonistou receptor\u016f GIP a GLP-1 a pat\u0159\u00ed mezi modifikovan\u00e9 inkretinov\u00e9 peptidy.<\/p><p data-start=\"378\" data-end=\"725\">Thirzepatid je molekula slo\u017een\u00e1 z 39 aminokyselin, jej\u00ed\u017e struktura byla navr\u017eena tak, aby zvy\u0161ovala metabolickou stabilitu a prodlu\u017eovala dobu \u00fa\u010dinku. Obsahuje modifikace, kter\u00e9 omezuj\u00ed enzymatickou degradaci, a lipidovou slo\u017eku, kter\u00e1 umo\u017e\u0148uje reverzibiln\u00ed vazbu na albumin. Molekulov\u00e1 hmotnost slou\u010deniny je p\u0159ibli\u017en\u011b 4813 Da.<\/p><p data-start=\"727\" data-end=\"930\">V laboratorn\u00edm kontextu je term\u00edn <em data-start=\"766\" data-end=\"783\">tirzepatidov\u00e9 pero<\/em> se t\u00fdk\u00e1 syst\u00e9mu pod\u00e1v\u00e1n\u00ed pou\u017eit\u00e9ho ve studii, zat\u00edmco samotn\u00e1 molekula z\u016fst\u00e1v\u00e1 p\u0159edm\u011btem farmakologick\u00fdch a molekul\u00e1rn\u00edch anal\u00fdz.<\/p><hr data-start=\"871\" data-end=\"874\" \/><h2 data-start=\"876\" data-end=\"937\">Thirzepatidov\u00e9 pero - mechanismus \u00fa\u010dinku (molekul\u00e1rn\u00ed p\u0159\u00edstup)<\/h2><p data-start=\"939\" data-end=\"1097\">Mechanismus \u00fa\u010dinku p\u0159\u00edpravku tirzepatide pen 10 mg je d\u00e1n vlastnostmi samotn\u00e9 molekuly tirzepatide jako agonisty inkretinov\u00fdch receptor\u016f pat\u0159\u00edc\u00edch do rodiny GPCR.<\/p><h3 data-start=\"1099\" data-end=\"1137\">Aktivace receptor\u016f GIP a GLP-1<\/h3><p data-start=\"1138\" data-end=\"1306\">Tirzepatidov\u00e9 pero vykazuje schopnost sou\u010dasn\u011b aktivovat GIPR a GLP-1R. Synergick\u00fd \u00fa\u010dinek t\u00e9to dvoj\u00ed aktivity byl analyzov\u00e1n v klinick\u00fdch studi\u00edch:<\/p><ul><li data-start=\"1310\" data-end=\"1346\">sekrece inzul\u00ednu z\u00e1visl\u00e1 na gluk\u00f3ze,<\/li><li data-start=\"1349\" data-end=\"1383\">inhibice sekrece glukagonu,<\/li><li data-start=\"1386\" data-end=\"1415\">regulace homeost\u00e1zy gluk\u00f3zy.<\/li><\/ul><h3 data-start=\"1417\" data-end=\"1451\">Vliv na vyprazd\u0148ov\u00e1n\u00ed \u017ealudku<\/h3><p data-start=\"1452\" data-end=\"1607\">V klinick\u00fdch modelech byl tirzepatide pen 10 mg spojen se zpomalen\u00edm gastrointestin\u00e1ln\u00ed motility, co\u017e souviselo s prodlou\u017eenou dobou vyprazd\u0148ov\u00e1n\u00ed \u017ealudku.<\/p><h3 data-start=\"1609\" data-end=\"1652\">Modulace centr\u00e1ln\u00edch drah sytosti<\/h3><p data-start=\"1653\" data-end=\"1833\">Receptory GLP-1 jsou p\u0159\u00edtomny ve struktur\u00e1ch centr\u00e1ln\u00edho nervov\u00e9ho syst\u00e9mu. Tato studie hodnotila \u00fa\u010dinky pera tirzepatide na sign\u00e1ly souvisej\u00edc\u00ed s regulac\u00ed chuti k j\u00eddlu a energetick\u00e9 rovnov\u00e1hy.<\/p><h3 data-start=\"1835\" data-end=\"1863\">Metabolick\u00e9 parametry<\/h3><p data-start=\"1864\" data-end=\"2056\">Klinick\u00e9 \u00fadaje o peru tirzepatide zahrnovaly anal\u00fdzu zm\u011bn t\u011blesn\u00e9 hmotnosti, glykemick\u00fdch ukazatel\u016f a lipidov\u00fdch parametr\u016f v z\u00e1vislosti na d\u00e1vce (5 mg, 10 mg, 15 mg) a dob\u011b sledov\u00e1n\u00ed.<\/p><hr data-start=\"2058\" data-end=\"2061\" \/><h2 data-start=\"2063\" data-end=\"2105\">Tirzepatidov\u00e9 pero v klinick\u00fdch studi\u00edch<\/h2><p data-start=\"2107\" data-end=\"2305\">Jedn\u00edm z nejcitovan\u011bj\u0161\u00edch v\u00fdzkumn\u00fdch projekt\u016f je <strong data-start=\"2165\" data-end=\"2206\"><span class=\"hover:entity-accent entity-underline inline cursor-pointer align-baseline\"><span class=\"whitespace-normal\">SURMOUNT-1<\/span><\/span><\/strong>, kter\u00fd hodnotil \u00fa\u010dinek tirzepatydu u subjekt\u016f s nadv\u00e1hou nebo obezitou ve v\u00fdzkumn\u00e9m protokolu.<\/p><p data-start=\"2307\" data-end=\"2519\">P\u0159i 72t\u00fddenn\u00edm sledov\u00e1n\u00ed byly prok\u00e1z\u00e1ny statisticky v\u00fdznamn\u00e9 rozd\u00edly oproti placebu, pokud jde o zm\u011bny t\u011blesn\u00e9 hmotnosti v z\u00e1vislosti na d\u00e1vce p\u0159i t\u00fddenn\u00edm re\u017eimu. Tirzepatidov\u00e9 pero bylo rovn\u011b\u017e analyzov\u00e1no z hlediska:<\/p><ul data-start=\"2521\" data-end=\"2629\"><li data-start=\"2521\" data-end=\"2537\"><p data-start=\"2523\" data-end=\"2537\">Zm\u011bny HbA1c,<\/p><\/li><li data-start=\"2538\" data-end=\"2568\"><p data-start=\"2540\" data-end=\"2568\">hladinu gluk\u00f3zy nala\u010dno,<\/p><\/li><li data-start=\"2569\" data-end=\"2592\"><p data-start=\"2571\" data-end=\"2592\">lipidov\u00fd profil,<\/p><\/li><li data-start=\"2593\" data-end=\"2629\"><p data-start=\"2595\" data-end=\"2629\">kardio-metabolick\u00e9 parametry.<\/p><\/li><\/ul><p data-start=\"2631\" data-end=\"2740\">Samostatn\u00e1 studie f\u00e1ze 3 srovn\u00e1vala tirzepatide s jin\u00fdmi agonisty GLP-1 u populace s diabetem 2. typu.<\/p><hr data-start=\"2742\" data-end=\"2745\" \/><h2 data-start=\"2813\" data-end=\"2861\">Bezpe\u010dnost a ne\u017e\u00e1douc\u00ed \u00fa\u010dinky - \u00fadaje uveden\u00e9 ve studi\u00edch<\/h2><p data-start=\"2805\" data-end=\"2932\">V klinick\u00fdch studi\u00edch pera tirzepatide 10 mg byly nej\u010dast\u011bji hl\u00e1\u0161eny gastrointestin\u00e1ln\u00ed p\u0159\u00edznaky, v\u010detn\u011b:<\/p><ul><li data-start=\"2936\" data-end=\"2947\">nevolnost,<\/li><li data-start=\"2950\" data-end=\"2960\">zvracen\u00ed,<\/li><li data-start=\"2963\" data-end=\"2974\">pr\u016fjem,<\/li><li data-start=\"2977\" data-end=\"2988\">z\u00e1cpa,<\/li><li data-start=\"2991\" data-end=\"3008\">pocit plnosti.<\/li><\/ul><p data-start=\"3010\" data-end=\"3203\">V\u00fdskyt ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f byl z\u00e1visl\u00fd na d\u00e1vce a f\u00e1zi eskalace. Tyto \u00fadaje poch\u00e1zej\u00ed z kontrolovan\u00fdch klinick\u00fdch studi\u00ed a z\u016fst\u00e1vaj\u00ed p\u0159edm\u011btem dal\u0161\u00edch dlouhodob\u00fdch anal\u00fdz.<\/p><hr data-start=\"3205\" data-end=\"3208\" \/><h2 data-start=\"3210\" data-end=\"3234\">V\u00fdzkumn\u00e9 vyu\u017eit\u00ed<\/h2><p data-start=\"3236\" data-end=\"3301\">V laboratorn\u00edm kontextu se s perem tirzepatide zach\u00e1z\u00ed jako s:<\/p><ul><li data-start=\"3305\" data-end=\"3346\">modelov\u00fd agonista receptor\u016f GIP\/GLP-1,<\/li><li data-start=\"3349\" data-end=\"3392\">n\u00e1stroj pro v\u00fdzkum signalizace GPCR,<\/li><li data-start=\"3395\" data-end=\"3474\">referen\u010dn\u00ed slou\u010denina v anal\u00fdz\u00e1ch metabolismu gluk\u00f3zy a regulace energie.<\/li><\/ul><p data-start=\"3476\" data-end=\"3603\">Produkt je ur\u010den pouze pro v\u00fdzkumn\u00e9 a analytick\u00e9 pou\u017eit\u00ed.<br data-start=\"3548\" data-end=\"3551\" \/>Nejedn\u00e1 se o dopln\u011bk stravy ani potravin\u00e1\u0159sk\u00fd v\u00fdrobek.<\/p><p data-start=\"3476\" data-end=\"3603\"><a href=\"https:\/\/tirzepatyd.eu\/de\/shop-produkt\/slu-pp-332\/\">Viz tak\u00e9 SLU-PP-332 60caps\/500mcg<\/a><\/p><hr data-start=\"3605\" data-end=\"3608\" \/><h3><a href=\"https:\/\/tirzepatyd.eu\/wp-content\/uploads\/2025\/09\/10mg-PEN-Camera.png\"><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter wp-image-30659 size-medium\" src=\"https:\/\/tirzepatyd.eu\/wp-content\/uploads\/2025\/09\/10mg-PEN-Camera-300x225.png\" alt=\"Tirzepatide Pen 10 mg GLP1 GIP peptid pro hubnut\u00ed \u010desk\u00e1 republika\" width=\"300\" height=\"225\" srcset=\"https:\/\/tirzepatyd.eu\/wp-content\/uploads\/2025\/09\/10mg-PEN-Camera-300x225.png 300w, https:\/\/tirzepatyd.eu\/wp-content\/uploads\/2025\/09\/10mg-PEN-Camera-800x600.png 800w, https:\/\/tirzepatyd.eu\/wp-content\/uploads\/2025\/09\/10mg-PEN-Camera-64x48.png 64w, https:\/\/tirzepatyd.eu\/wp-content\/uploads\/2025\/09\/10mg-PEN-Camera-768x576.png 768w, https:\/\/tirzepatyd.eu\/wp-content\/uploads\/2025\/09\/10mg-PEN-Camera-16x12.png 16w, https:\/\/tirzepatyd.eu\/wp-content\/uploads\/2025\/09\/10mg-PEN-Camera.png 1024w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><\/h3><div><p data-start=\"3610\" data-end=\"3627\">V\u011bdeck\u00e9 zdroje:<\/p><ol data-start=\"3629\" data-end=\"3989\"><li data-start=\"3629\" data-end=\"3799\"><p data-start=\"3632\" data-end=\"3799\">Jastreboff AM et al. Tirzepatid jednou t\u00fddn\u011b k l\u00e9\u010db\u011b obezity. <em data-start=\"3707\" data-end=\"3740\">New England Journal of Medicine<\/em>, 2022.<br data-start=\"3747\" data-end=\"3750\" \/>PubMed: <a class=\"decorated-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35658024\/\" target=\"_new\" rel=\"noopener\" data-start=\"3758\" data-end=\"3799\">https:\/\/pubmed.ncbi.nlm.nih.gov\/35658024\/<\/a><\/p><\/li><li data-start=\"3801\" data-end=\"3989\"><p data-start=\"3804\" data-end=\"3989\">Fr\u00edas JP et al. Tirzepatid versus semaglutid jednou t\u00fddn\u011b u pacient\u016f s diabetem 2. typu. <em data-start=\"3897\" data-end=\"3930\">New England Journal of Medicine<\/em>, 2021.<br data-start=\"3937\" data-end=\"3940\" \/>PubMed: <a class=\"decorated-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35579691\/\" target=\"_new\" rel=\"noopener\" data-start=\"3948\" data-end=\"3989\">https:\/\/pubmed.ncbi.nlm.nih.gov\/35579691\/<\/a><\/p><\/li><\/ol><hr data-start=\"3605\" data-end=\"3608\" \/><p><strong>V\u00fdrobek je ur\u010den pro v\u011bdeck\u00fd v\u00fdzkum a laboratorn\u00ed anal\u00fdzy. V\u0161echny \u010dl\u00e1nky a informace na t\u011bchto webov\u00fdch str\u00e1nk\u00e1ch slou\u017e\u00ed pouze k informa\u010dn\u00edm a vzd\u011bl\u00e1vac\u00edm \u00fa\u010del\u016fm.<\/strong><\/p><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p><strong data-start=\"91\" data-end=\"116\">Tirzepatid pero 10 mg<\/strong> je vysoce kvalitn\u00ed syntetick\u00fd peptid s du\u00e1ln\u00ed aktivitou v\u016f\u010di receptor\u016fm GIP a GLP-1 pro pokro\u010dil\u00e9 v\u00fdzkumn\u00e9 projekty t\u00fdkaj\u00edc\u00ed se metabolismu, t\u011blesn\u00e9 hmotnosti a regulace energetick\u00e9 homeost\u00e1zy.<\/p>","protected":false},"featured_media":30659,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[122,111,15],"product_tag":[],"class_list":{"0":"post-20220","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-produkty-w-penie","7":"product_cat-glp1gip","8":"product_cat-laboratory-research","10":"first","11":"outofstock","12":"sale","13":"shipping-taxable","14":"purchasable","15":"product-type-simple"},"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/product\/20220","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/comments?post=20220"}],"version-history":[{"count":26,"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/product\/20220\/revisions"}],"predecessor-version":[{"id":35460,"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/product\/20220\/revisions\/35460"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/media\/30659"}],"wp:attachment":[{"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/media?parent=20220"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/product_brand?post=20220"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/product_cat?post=20220"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/product_tag?post=20220"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}