{"id":13028,"date":"2023-07-24T23:07:01","date_gmt":"2023-07-24T21:07:01","guid":{"rendered":"https:\/\/tirzepatyd.eu\/?post_type=product&#038;p=13028"},"modified":"2026-03-26T11:16:39","modified_gmt":"2026-03-26T10:16:39","slug":"glp1-gip-tirzepatide-2-5-mg","status":"publish","type":"product","link":"https:\/\/tirzepatyd.eu\/cs\/obchod-produkt\/glp1-gip-tirzepatide-2-5-mg\/","title":{"rendered":"Tirzepatid 2,5 mg injek\u010dn\u00ed lahvi\u010dka (GLP1+GIP)"},"content":{"rendered":"<div data-elementor-type=\"product-post\" data-elementor-id=\"13028\" class=\"elementor elementor-13028\" data-elementor-post-type=\"product\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-53f3d7d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"53f3d7d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e6006d1\" data-id=\"e6006d1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-64391bc elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"64391bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<h2 data-start=\"512\" data-end=\"564\">Tirzepatid 2,5 mg lahvi\u010dka - charakteristika<\/h2><p data-start=\"566\" data-end=\"843\"><strong data-start=\"566\" data-end=\"588\">Tirzepatid 2,5 mg<\/strong> je syntetick\u00fd peptid, kter\u00fd je du\u00e1ln\u00edm agonistou receptor\u016f GIP a GLP-1. Tato slou\u010denina byla ve v\u011bdeck\u00e9 literatu\u0159e rozs\u00e1hle studov\u00e1na v souvislosti s inkretinovou signalizac\u00ed, regulac\u00ed metabolismu gluk\u00f3zy a mechanismy \u0159\u00edzen\u00ed energetick\u00e9 rovnov\u00e1hy.<\/p><hr data-start=\"908\" data-end=\"911\" \/><h2 data-start=\"913\" data-end=\"982\">Co je tirzepatide 2,5 mg a jak\u00fd je jeho mechanismus \u00fa\u010dinku?<\/h2><p data-start=\"984\" data-end=\"1093\">Tirzepatid je jedin\u00e1 molekula ur\u010den\u00e1 k sou\u010dasn\u00e9 aktivaci dvou inkretinov\u00fdch receptor\u016f:<\/p><ul data-start=\"1095\" data-end=\"1428\"><li data-start=\"1095\" data-end=\"1271\"><p data-start=\"1097\" data-end=\"1271\"><strong data-start=\"1097\" data-end=\"1150\">GLP-1 receptor (receptor pro glukagonu podobn\u00fd peptid-1)<\/strong> - spojen\u00e9 se sekrec\u00ed inzul\u00ednu z\u00e1vislou na gluk\u00f3ze, modulac\u00ed sekrece glukagonu a vlivem na signalizaci sytosti.<\/p><\/li><li data-start=\"1272\" data-end=\"1428\"><p data-start=\"1274\" data-end=\"1428\"><strong data-start=\"1274\" data-end=\"1346\">GIP receptor (gluk\u00f3zo-dependentn\u00ed inzulinotropn\u00ed polypeptidov\u00fd receptor)<\/strong> - pod\u00edlej\u00ed na regulaci inzul\u00ednov\u00e9 odpov\u011bdi a metabolick\u00fdch proces\u016f.<\/p><\/li><\/ul><p data-start=\"1430\" data-end=\"1726\">Dvoj\u00ed aktivace t\u011bchto drah odli\u0161uje tirzepatide od klasick\u00fdch agonist\u016f GLP-1. Tento mechanismus byl podrobn\u011b pops\u00e1n v klinick\u00fdch studi\u00edch SURPASS a SURMOUNT, kde byly za kontrolovan\u00fdch studijn\u00edch podm\u00ednek analyzov\u00e1ny \u00fa\u010dinky molekuly na glykemick\u00e9 parametry a t\u011blesnou hmotnost.<\/p><hr data-start=\"1728\" data-end=\"1731\" \/><h2 data-start=\"1733\" data-end=\"1777\">Tirzepatid 2,5 mg v klinick\u00fdch modelech<\/h2><p data-start=\"1779\" data-end=\"1879\">tirzepatide jako t\u0159\u00edda inkretinov\u00fdch molekul byla prok\u00e1z\u00e1na v publikovan\u00fdch klinick\u00fdch studi\u00edch:<\/p><ul data-start=\"1881\" data-end=\"2079\"><li data-start=\"1881\" data-end=\"1942\"><p data-start=\"1883\" data-end=\"1942\">v\u00fdznamn\u011b ovliv\u0148uje parametry metabolismu gluk\u00f3zy (HbA1c),<\/p><\/li><li data-start=\"1943\" data-end=\"2013\"><p data-start=\"1945\" data-end=\"2013\">ovliv\u0148uje mechanismy reguluj\u00edc\u00ed chu\u0165 k j\u00eddlu a energetickou bilanci,<\/p><\/li><li data-start=\"2014\" data-end=\"2079\"><p data-start=\"2016\" data-end=\"2079\">ukazuje z\u00e1vislost \u00fa\u010dinku na d\u00e1vce v eskala\u010dn\u00edch protokolech.<\/p><\/li><\/ul><p data-start=\"2081\" data-end=\"2259\">D\u00e1vka 2,5 mg v klinick\u00fdch re\u017eimech slou\u017eila jako po\u010d\u00e1te\u010dn\u00ed d\u00e1vka v modelech eskalace, co\u017e umo\u017enilo posoudit toleranci organismu a adaptaci na dal\u0161\u00ed \u00farovn\u011b d\u00e1vek.<\/p><hr data-start=\"2261\" data-end=\"2264\" \/><h2 data-start=\"2266\" data-end=\"2304\">Rozd\u00edl: tirzepatide 2,5 mg vs 5 mg<\/h2><p data-start=\"2306\" data-end=\"2339\">V dokumentaci klinick\u00e9ho hodnocen\u00ed:<\/p><ul data-start=\"2341\" data-end=\"2486\"><li data-start=\"2341\" data-end=\"2401\"><p data-start=\"2343\" data-end=\"2401\"><strong data-start=\"2343\" data-end=\"2365\">tirzepatide 2,5 mg<\/strong> byla pou\u017eita jako \u00favodn\u00ed d\u00e1vka,<\/p><\/li><li data-start=\"2402\" data-end=\"2486\"><p data-start=\"2404\" data-end=\"2486\">U vy\u0161\u0161\u00edch d\u00e1vek (5 mg a v\u00edce) byly analyzov\u00e1ny v\u0161echny metabolick\u00e9 \u00fa\u010dinky.<\/p><\/li><\/ul><p data-start=\"2488\" data-end=\"2633\">Hodnocen\u00ed \u00fa\u010dinnosti z hlediska sn\u00ed\u017een\u00ed hmotnosti bylo provedeno p\u0159edev\u0161\u00edm u vy\u0161\u0161\u00edch d\u00e1vek v kontrolovan\u00fdch podm\u00ednk\u00e1ch studie.<\/p><hr data-start=\"2635\" data-end=\"2638\" \/><h2 data-start=\"2640\" data-end=\"2664\">Kvalitativn\u00ed informace<\/h2><p data-start=\"2666\" data-end=\"2812\">Nab\u00edzeno <strong data-start=\"2676\" data-end=\"2698\">tirzepatide 2,5 mg<\/strong> se podrob\u00ed kvalitativn\u00ed anal\u00fdze (nap\u0159. HPLC), aby se potvrdila \u010distota a shoda s laboratorn\u00edmi specifikacemi.<\/p><p data-start=\"2814\" data-end=\"2935\">V\u00fdrobek nen\u00ed l\u00e9\u010div\u00fdm p\u0159\u00edpravkem ani dopl\u0148kem stravy.<br data-start=\"2868\" data-end=\"2871\" \/>Ur\u010deno pouze pro v\u00fdzkumn\u00e9 a analytick\u00e9 aplikace.<\/p><hr data-start=\"2937\" data-end=\"2940\" \/><h2 data-start=\"220\" data-end=\"260\">\u00dadaje z klinick\u00e9 studie SURMOUNT-1<\/h2><p data-start=\"262\" data-end=\"420\">V randomizovan\u00e9 klinick\u00e9 studii f\u00e1ze III <strong data-start=\"307\" data-end=\"321\">SURMOUNT-1<\/strong> (NEJM, 2022) hodnotila vliv tirzepatide na t\u011blesnou hmotnost u ob\u00e9zn\u00edch jedinc\u016f nebo jedinc\u016f s nadv\u00e1hou bez diabetu.<\/p><p data-start=\"422\" data-end=\"572\">Ve studii bylo pou\u017eito sch\u00e9ma zvy\u0161ov\u00e1n\u00ed d\u00e1vky, kter\u00e9 za\u010d\u00ednalo d\u00e1vkou <strong data-start=\"490\" data-end=\"500\">2,5 mg<\/strong>, a n\u00e1sledn\u011b zv\u00fd\u0161ena na c\u00edlov\u00e9 hladiny (5 mg, 10 mg, 15 mg).<\/p><p data-start=\"574\" data-end=\"602\">Po 72 t\u00fddnech sledov\u00e1n\u00ed:<\/p><ul data-start=\"604\" data-end=\"801\"><li data-start=\"604\" data-end=\"674\"><p data-start=\"606\" data-end=\"674\">Pr\u016fm\u011brn\u00e9 sn\u00ed\u017een\u00ed hmotnosti bylo p\u0159ibli\u017en\u011b <strong data-start=\"649\" data-end=\"671\">15% pro d\u00e1vku 5 mg<\/strong>,<\/p><\/li><li data-start=\"675\" data-end=\"711\"><p data-start=\"677\" data-end=\"711\">O str\u00e1nk\u00e1ch <strong data-start=\"683\" data-end=\"708\">19,5% pro d\u00e1vku 10 mg<\/strong>,<\/p><\/li><li data-start=\"712\" data-end=\"748\"><p data-start=\"714\" data-end=\"748\">O str\u00e1nk\u00e1ch <strong data-start=\"720\" data-end=\"745\">20,9% pro d\u00e1vku 15 mg<\/strong>,<\/p><\/li><li data-start=\"749\" data-end=\"801\"><p data-start=\"751\" data-end=\"801\">Ve skupin\u011b s placebem bylo sn\u00ed\u017een\u00ed p\u0159ibli\u017en\u011b o <strong data-start=\"792\" data-end=\"800\">3.1%<\/strong>.<\/p><\/li><\/ul><p data-start=\"803\" data-end=\"931\">Krom\u011b toho bylo pozorov\u00e1no zlep\u0161en\u00ed metabolick\u00fdch parametr\u016f, v\u010detn\u011b zm\u011bn lipidov\u00e9ho profilu a ukazatel\u016f metabolismu gluk\u00f3zy.<\/p><p data-start=\"933\" data-end=\"1115\">Je t\u0159eba zd\u016fraznit, \u017ee <strong data-start=\"954\" data-end=\"1028\">d\u00e1vka 2,5 mg v klinick\u00fdch studi\u00edch slou\u017eila jako \u00favodn\u00ed d\u00e1vka.<\/strong>, pou\u017e\u00edv\u00e1 ke zlep\u0161en\u00ed tolerance p\u0159ed dosa\u017een\u00edm vy\u0161\u0161\u00edch d\u00e1vek.<\/p><hr data-start=\"2937\" data-end=\"2940\" \/><p data-start=\"2942\" data-end=\"2960\"><a href=\"https:\/\/tirzepatyd.eu\/wp-content\/uploads\/2025\/09\/2.5mg-0.5ml-Camera.png\"><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter wp-image-30655 size-medium\" src=\"https:\/\/tirzepatyd.eu\/wp-content\/uploads\/2025\/09\/2.5mg-0.5ml-Camera-300x225.png\" alt=\"Tirzepatid 2,5 mg lahvi\u010dka - du\u00e1ln\u00ed GLP-1\/GIP v\u00fdzkumn\u00fd peptid, vysok\u00e1 \u010distota\" width=\"300\" height=\"225\" srcset=\"https:\/\/tirzepatyd.eu\/wp-content\/uploads\/2025\/09\/2.5mg-0.5ml-Camera-300x225.png 300w, https:\/\/tirzepatyd.eu\/wp-content\/uploads\/2025\/09\/2.5mg-0.5ml-Camera-800x600.png 800w, https:\/\/tirzepatyd.eu\/wp-content\/uploads\/2025\/09\/2.5mg-0.5ml-Camera-64x48.png 64w, https:\/\/tirzepatyd.eu\/wp-content\/uploads\/2025\/09\/2.5mg-0.5ml-Camera-768x576.png 768w, https:\/\/tirzepatyd.eu\/wp-content\/uploads\/2025\/09\/2.5mg-0.5ml-Camera-16x12.png 16w, https:\/\/tirzepatyd.eu\/wp-content\/uploads\/2025\/09\/2.5mg-0.5ml-Camera.png 1024w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><\/p><p data-start=\"2942\" data-end=\"2960\">V\u011bdeck\u00fd zdroj<\/p><p data-start=\"2962\" data-end=\"3131\">Jastreboff AM et al, <em data-start=\"2984\" data-end=\"3038\">Tirzepatid jednou t\u00fddn\u011b k l\u00e9\u010db\u011b obezity<\/em>, New England Journal of Medicine, 2022.<br data-start=\"3078\" data-end=\"3081\" \/><a class=\"decorated-link\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10088547\/\" target=\"_new\" rel=\"noopener\" data-start=\"3081\" data-end=\"3131\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10088547\/<\/a><\/p><hr data-start=\"2937\" data-end=\"2940\" \/><p data-start=\"2962\" data-end=\"3131\"><strong>V\u00fdrobek je ur\u010den pro v\u011bdeck\u00fd v\u00fdzkum a laboratorn\u00ed anal\u00fdzy. V\u0161echny \u010dl\u00e1nky a informace na t\u011bchto webov\u00fdch str\u00e1nk\u00e1ch slou\u017e\u00ed pouze k informa\u010dn\u00edm a vzd\u011bl\u00e1vac\u00edm \u00fa\u010del\u016fm.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p><strong data-start=\"116\" data-end=\"138\">Tirzepatid 2,5 mg<\/strong> je syntetick\u00fd peptid s dvoj\u00ed aktivitou v\u016f\u010di receptor\u016fm GIP (gluk\u00f3zo-inzulinotropn\u00ed peptid) a GLP-1 (glukagonu podobn\u00fd peptid-1). Tato slou\u010denina je p\u0159edm\u011btem v\u00fdzkumu inkretinov\u00e9 signalizace, regulace metabolismu gluk\u00f3zy a mechanism\u016f \u0159\u00edzen\u00ed energetick\u00e9 rovnov\u00e1hy.<\/p>","protected":false},"featured_media":30655,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[124,111,15],"product_tag":[136],"class_list":{"0":"post-13028","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-produkty-w-fiolce","7":"product_cat-glp1gip","8":"product_cat-laboratory-research","9":"product_tag-fiolka","11":"first","12":"instock","13":"shipping-taxable","14":"purchasable","15":"product-type-variable"},"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/product\/13028","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/comments?post=13028"}],"version-history":[{"count":14,"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/product\/13028\/revisions"}],"predecessor-version":[{"id":35111,"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/product\/13028\/revisions\/35111"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/media\/30655"}],"wp:attachment":[{"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/media?parent=13028"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/product_brand?post=13028"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/product_cat?post=13028"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/product_tag?post=13028"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}