{"id":11835,"date":"2023-04-16T00:40:42","date_gmt":"2023-04-15T22:40:42","guid":{"rendered":"https:\/\/tirzepatyd.eu\/?page_id=11835"},"modified":"2025-12-16T05:05:23","modified_gmt":"2025-12-16T04:05:23","slug":"tirzepatid","status":"publish","type":"page","link":"https:\/\/tirzepatyd.eu\/cs\/tirzepatid\/","title":{"rendered":"Tirzepatid"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"11835\" class=\"elementor elementor-11835\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ba19006 e-con-full e-flex e-con e-parent\" data-id=\"ba19006\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-debb04e e-flex e-con-boxed e-con e-child\" data-id=\"debb04e\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-ae058b9 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"ae058b9\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2edbf0b elementor-widget elementor-widget-heading\" data-id=\"2edbf0b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Thirzepatid - jak funguje?<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ddb96e3 e-flex e-con-boxed e-con e-parent\" data-id=\"ddb96e3\" data-element_type=\"container\" data-settings=\"{&quot;shape_divider_top&quot;:&quot;tilt&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 1000 100\" preserveaspectratio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M0,6V0h1000v100L0,6z\"\/>\n<\/svg>\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1f971a5 e-con-full e-flex e-con e-child\" data-id=\"1f971a5\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-398f39f elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"398f39f\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Agonist\u00e9 peptidov\u00fdch inkretinov\u00fdch receptor\u016f<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ab9f111 elementor-invisible elementor-widget elementor-widget-ucaddon_ue_unfold\" data-id=\"ab9f111\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"ucaddon_ue_unfold.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n<!-- start Unfold Content -->\n\t\t<link id='font-awesome-css' href='https:\/\/tirzepatyd.eu\/wp-content\/plugins\/unlimited-elements-for-elementor-premium\/assets_libraries\/font-awesome6\/fontawesome-all.min.css' type='text\/css' rel='stylesheet' >\n\t\t<link id='font-awesome-4-shim-css' href='https:\/\/tirzepatyd.eu\/wp-content\/plugins\/unlimited-elements-for-elementor-premium\/assets_libraries\/font-awesome6\/fontawesome-v4-shims.min.css' type='text\/css' rel='stylesheet' >\n\n<style>\/* widget: Unfold Content *\/\n\n#uc_ue_unfold_elementor_ab9f111{\n opacity: 0;\n transition: opacity .2s;\n}\n\n#uc_ue_unfold_elementor_ab9f111.ue-full-opacity{\n opacity: 1;\n}\n\n#uc_ue_unfold_elementor_ab9f111 .unfold_wrapper{\n  max-height:100%;\n  width: 100%;\n}\n\n#uc_ue_unfold_elementor_ab9f111 .unfold_card{\n  position: relative;\n  overflow:hidden;\n}\n\n#uc_ue_unfold_elementor_ab9f111 .uf_overlayuc_ue_unfold_elementor_ab9f111{\n    position: absolute;\n    right: 0;\n    bottom: 0;\n    left: 0;\n    z-index: 1;\n    background: -moz-linear-gradient(0deg, #ffffff) 10%, rgba(255, 255, 255, 0) 100%);\n    background: -webkit-linear-gradient(0deg, #ffffff 10%, rgba(255, 255, 255, 0) 100%);\n    background: linear-gradient(0deg, #ffffff 10%, rgba(255, 255, 255, 0) 100%);\n}\n\n#uc_ue_unfold_elementor_ab9f111 .ue-btn-wrap{\n        display: flex;   \n    position:relative;\n  z-index:2;\n}\n\n#uc_ue_unfold_elementor_ab9f111 #button_uc_ue_unfold_elementor_ab9f111{\n    display: flex;\n    justify-content: center;\n    align-items: center;\n    cursor:pointer;\n    transition:0.3s;\n}\n\n#uc_ue_unfold_elementor_ab9f111 .ue_unfold_title,\n#uc_ue_unfold_elementor_ab9f111 .ue-txt{\n  transition: all .3s ease;\n}\n\n.ue-btn-icon{\n  line-height:1em;\n}\n\n.ue-btn-icon svg{\n  height:1em;\n  width:1em;\n}\n\n#uc_ue_unfold_elementor_ab9f111 .unfold_wrapper{\n  overflow:hidden;\n  transition:300ms;\n}\n\n#uf_overlayuc_ue_unfold_elementor_ab9f111{\n  transition:300ms;\n}\n\n#uc_ue_unfold_elementor_ab9f111 .unfold_wrapper.ue-unfold-active #uf_overlayuc_ue_unfold_elementor_ab9f111{\n  height:0px;\n}\n\n#ue-icon-unfolded-uc_ue_unfold_elementor_ab9f111{\n  display:none;\n}\n\n#ue-text-unfolded-uc_ue_unfold_elementor_ab9f111{\n  display:none;\n}\n\n#uc_ue_unfold_elementor_ab9f111  button{\n  outline:none;\n}\n\n<\/style>\n\n\n<div id=\"uc_ue_unfold_elementor_ab9f111\" data-scroll-back=\"true\">\n  \n  \n  <div class=\"unfold_card\">\n    <div class=\"unfold_wrapper\" id=\"unfold_wrapper_uc_ue_unfold_elementor_ab9f111\">\n      <div class=\"uf_overlayuc_ue_unfold_elementor_ab9f111 uf_overlay\" id=\"uf_overlayuc_ue_unfold_elementor_ab9f111\"><\/div>\n                          <div class=\"ue-txt\"><div class=\"elementor-element elementor-element-e20e02e elementor-widget elementor-widget-text-editor\" data-id=\"e20e02e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\"><div class=\"elementor-widget-container\"><div class=\"elementor-element elementor-element-d08f889 elementor-widget elementor-widget-text-editor\" data-id=\"d08f889\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\"><div class=\"elementor-widget-container\"><section class=\"elementor-section elementor-top-section elementor-element elementor-element-4e0cfc7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4e0cfc7\" data-element_type=\"section\"><div class=\"elementor-container elementor-column-gap-default\"><div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-efa4c37\" data-id=\"efa4c37\" data-element_type=\"column\"><div class=\"elementor-widget-wrap elementor-element-populated\"><div class=\"elementor-element elementor-element-d97df69 elementor-widget elementor-widget-text-editor\" data-id=\"d97df69\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\"><div class=\"elementor-widget-container\"><p>N\u00e1sleduj\u00edc\u00ed slou\u010deniny jsou pokro\u010dil\u00fdmi modul\u00e1tory metabolick\u00fdch drah studovan\u00fdmi v kontextu jejich \u00fa\u010dink\u016f na receptory. <strong>GLP-1<\/strong>, <strong>GIP<\/strong> i <strong>glukagon<\/strong>. V\u00fdzkum upozor\u0148uje na rozd\u00edly v \u00fa\u010dinnosti, selektivit\u011b receptor\u016f a dynamice metabolick\u00e9 odezvy.<\/p><p><strong>1. thirzepatid<\/strong><\/p><p><strong>Hlavn\u00ed \u00fa\u010dinky pozorovan\u00e9 ve studii<\/strong><\/p><ul><li>silnou aktivaci receptor\u016f GLP-1 a GIP, co\u017e podle studi\u00ed vede k v\u00fdrazn\u00e9mu synergick\u00e9mu \u00fa\u010dinku,<\/li><li>jasn\u00fd vliv na regulaci chuti k j\u00eddlu a sytosti,<\/li><li>v\u00fdznamn\u00e9 zlep\u0161en\u00ed parametr\u016f gluk\u00f3zy v experiment\u00e1ln\u00edch modelech,<\/li><li>p\u0159\u00edzniv\u00e9 \u00fa\u010dinky na metabolismus lipid\u016f.<\/li><\/ul><p><strong>Jak to funguje?<\/strong><\/p><p>Thiogastatid je peptid s dvoj\u00edm zac\u00edlen\u00edm (du\u00e1ln\u00ed agonista). Publikace uk\u00e1zaly, \u017ee sou\u010dasn\u00e1 aktivace GLP-1 a GIP zesiluje sign\u00e1ly zodpov\u011bdn\u00e9 za regulaci energetick\u00e9ho metabolismu v\u00edce ne\u017e selektivn\u00ed agonist\u00e9 GLP-1. Studie tak\u00e9 prok\u00e1zaly, \u017ee jeho p\u016fsoben\u00ed zlep\u0161uje metabolickou citlivost a sni\u017euje p\u0159\u00edjem energie na zv\u00ed\u0159ec\u00edch a bun\u011b\u010dn\u00fdch modelech.<\/p><p><strong>2. retatrutid<\/strong><\/p><p><strong>Hlavn\u00ed \u00fa\u010dinky pozorovan\u00e9 ve studii<\/strong><\/p><ul><li>sou\u010dasn\u00e1 aktivace a\u017e t\u0159\u00ed receptor\u016f: GLP-1, GIP a glukagonu,<\/li><li>siln\u011bj\u0161\u00ed metabolick\u00fd \u00fa\u010dinek ne\u017e slou\u010deniny s du\u00e1ln\u00ed aktivac\u00ed,<\/li><li>zv\u00fd\u0161en\u00e9 spalov\u00e1n\u00ed energie a vy\u0161\u0161\u00ed termogenn\u00ed \u00fa\u010dinek v experiment\u00e1ln\u00edch modelech,<\/li><li>vliv na zlep\u0161en\u00ed lipidov\u00e9ho profilu.<\/li><\/ul><p><strong>Jak to funguje?<\/strong><\/p><p>Retatrutid je takzvan\u00fd trojit\u00fd agonista neboli modul\u00e1tor t\u0159\u00ed receptor\u016f. V preklinick\u00fdch a \u010dasn\u00fdch klinick\u00fdch studi\u00edch bylo prok\u00e1z\u00e1no, \u017ee aktivace glukagonov\u00e9ho receptoru zvy\u0161uje energetick\u00fd v\u00fddej a v kombinaci s GLP-1 a GIP vede k nejsiln\u011bj\u0161\u00edmu metabolick\u00e9mu \u00fa\u010dinku ze v\u0161ech dosud zn\u00e1m\u00fdch inkretinov\u00fdch analog. V\u00fdzkumy zd\u016fraz\u0148uj\u00ed jeho prodlou\u017een\u00e9 trv\u00e1n\u00ed aktivity a vysokou \u00fa\u010dinnost.<\/p><p><strong>3. Semaglutid<\/strong><\/p><p><strong>Hlavn\u00ed \u00fa\u010dinky pozorovan\u00e9 ve studii<\/strong><\/p><ul><li>vysoce selektivn\u00ed aktivace receptoru GLP-1,<\/li><li>v\u00fdznamn\u00e9 sn\u00ed\u017een\u00ed chuti k j\u00eddlu a zv\u00fd\u0161en\u00ed pocitu sytosti v experiment\u00e1ln\u00edch modelech,<\/li><li>zlep\u0161en\u00ed kontroly glyk\u00e9mie,<\/li><li>velmi dlouh\u00e9 trv\u00e1n\u00ed \u00fa\u010dinku d\u00edky stabilit\u011b molekuly.<\/li><\/ul><p><strong>Jak to funguje?<\/strong><\/p><p>Semaglutid je klasick\u00fd, siln\u00fd agonista GLP-1 s prodlou\u017eenou aktivitou. Ve v\u00fdzkumn\u00fdch studi\u00edch vykazuje konzistentn\u00ed, p\u0159edv\u00eddateln\u00fd profil \u00fa\u010dinku d\u00edky struktur\u00e1ln\u00edm modifikac\u00edm, kter\u00e9 zvy\u0161uj\u00ed jeho vazbu na albumin. Je \u0161iroce pou\u017e\u00edv\u00e1n jako referen\u010dn\u00ed (\"zlat\u00fd standard\") pro srovn\u00e1vac\u00ed studie s nov\u011bj\u0161\u00edmi multireceptorov\u00fdmi agonisty.<\/p><p><strong>4. orforglipron<\/strong><\/p><p><strong>Hlavn\u00ed \u00fa\u010dinky pozorovan\u00e9 ve studii<\/strong><\/p><ul><li>Siln\u00e1 agonistick\u00e1 aktivace GLP-1 p\u0159i zachov\u00e1n\u00ed formy mal\u00e9 molekuly (nepeptidov\u00e9),<\/li><li>vy\u0161\u0161\u00ed biologickou dostupnost ve srovn\u00e1n\u00ed s klasick\u00fdmi peptidy,<\/li><li>Potenci\u00e1ln\u011b rychlej\u0161\u00ed provozn\u00ed dynamika,<\/li><li>modulace sytosti a postprandi\u00e1ln\u00edch metabolick\u00fdch parametr\u016f.<\/li><\/ul><p><strong>Jak to funguje?<\/strong><\/p><p>Orforglipron (d\u0159\u00edve LY3502970) je jedn\u00edm z prvn\u00edch nepeptidov\u00fdch agonist\u016f GLP-1. Na rozd\u00edl od typick\u00fdch peptid\u016f je stabiln\u00ed malou molekulou, co\u017e mu d\u00e1v\u00e1 jedine\u010dn\u00fd farmakokinetick\u00fd profil. Studie ukazuj\u00ed podobn\u00e9 \u00fa\u010dinky jako u klasick\u00fdch agonist\u016f GLP-1, ale s odli\u0161nou farmakodynamikou, co\u017e z n\u011bj \u010din\u00ed zaj\u00edmav\u00fd n\u00e1stroj pro nov\u00e9 v\u00fdzkumn\u00e9 modely.<\/p><p><strong>Srovn\u00e1n\u00ed na z\u00e1klad\u011b v\u011bdeck\u00fdch zdroj\u016f<\/strong><\/p><table><thead><tr><th>L\u00e1tka<\/th><th>Mechanismus<\/th><th>Nejsiln\u011bj\u0161\u00ed \u00fa\u010dinek (podle studi\u00ed)<\/th><th>Kl\u00ed\u010dov\u00e1 vlastnost<\/th><\/tr><\/thead><tbody><tr><td><strong>Tirzepatid<\/strong><\/td><td>GLP-1 + GIP<\/td><td>Siln\u00fd syt\u00edc\u00ed efekt a sn\u00ed\u017een\u00ed p\u0159\u00edjmu energie<\/td><td>Synergick\u00e1 du\u00e1ln\u00ed aktivace<\/td><\/tr><tr><td><strong>Retatrutid<\/strong><\/td><td>GLP-1 + GIP + glukagon<\/td><td>Nejvy\u0161\u0161\u00ed spot\u0159eba energie, siln\u00fd metabolick\u00fd dopad<\/td><td>Trojit\u00fd agonista - nej\u0161ir\u0161\u00ed receptorov\u00fd profil<\/td><\/tr><tr><td><strong>Semaglutid<\/strong><\/td><td>GLP-1<\/td><td>Stabiln\u00ed, p\u0159edv\u00eddateln\u00fd metabolick\u00fd \u00fa\u010dinek<\/td><td>Jedin\u00e1 aktivace<\/td><\/tr><tr><td><strong>Orforglipron<\/strong><\/td><td>GLP-1 (nepeptid)<\/td><td>Vysok\u00e1 biologick\u00e1 dostupnost a odli\u0161n\u00e1 farmakokinetika<\/td><td>Mal\u00e1 molekula - jedine\u010dn\u00fd mechanismus \u00fa\u010dinku<\/td><\/tr><\/tbody><\/table><hr \/><\/div><\/div><\/div><\/div><\/div><\/section><\/div><\/div><\/div><\/div><\/div>\n            <\/div>\n  \n      <div class=\"ue-btn-wrap\" id=\"btn_wrapper btn_wrapper_uc_ue_unfold_elementor_ab9f111\"> \n    <a href=\"javascript:void(0)\" role=\"button\" class=\"ubfold_btn\" id=\"button_uc_ue_unfold_elementor_ab9f111\">\n              <span class=\"ue-btn-icon\" id=\"ue-icon-folded-uc_ue_unfold_elementor_ab9f111\"><i class='fas fa-angle-down'><\/i><\/span>\n        <span class=\"ue-btn-icon\" id=\"ue-icon-unfolded-uc_ue_unfold_elementor_ab9f111\"><i class='fas fa-angle-up'><\/i><\/span>\n            <span id=\"ue-text-folded-uc_ue_unfold_elementor_ab9f111\">P\u0159e\u010dt\u011bte si v\u00edce<\/span>\n      <span id=\"ue-text-unfolded-uc_ue_unfold_elementor_ab9f111\">V\u00edce informac\u00ed<\/span>\n    <\/a>\n  <\/div>\n\t\n  \n  <\/div>\n  <\/div>\n<!-- end Unfold Content -->\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0167030 e-flex e-con-boxed e-con e-parent\" data-id=\"0167030\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-795ca6a e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"795ca6a\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-6740063 e-con-full e-flex e-con e-child\" data-id=\"6740063\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-64cc5ef e-con-full e-flex e-con e-child\" data-id=\"64cc5ef\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9e88f93 elementor-widget elementor-widget-image\" data-id=\"9e88f93\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/tirzepatyd.eu\/wp-content\/uploads\/2025\/12\/tirze-e1751526038397.png\" title=\"\" alt=\"\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ea2f262 elementor-widget__width-inherit elementor-widget elementor-widget-counter\" data-id=\"ea2f262\" data-element_type=\"widget\" data-widget_type=\"counter.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-counter\">\n\t\t\t<div class=\"elementor-counter-title\">Graf GLP-1+GIP<\/div>\t\t\t<div class=\"elementor-counter-number-wrapper\">\n\t\t\t\t<span class=\"elementor-counter-number-prefix\"><\/span>\n\t\t\t\t<span class=\"elementor-counter-number\" data-duration=\"2000\" data-to-value=\"25\" data-from-value=\"0\">0<\/span>\n\t\t\t\t<span class=\"elementor-counter-number-suffix\">kg<\/span>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b9f8419 e-con-full e-flex e-con e-child\" data-id=\"b9f8419\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8243c1a elementor-widget elementor-widget-image\" data-id=\"8243c1a\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/tirzepatyd.eu\/wp-content\/uploads\/2025\/12\/semag-e1751526052912.png\" title=\"\" alt=\"\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c025bff elementor-widget__width-inherit elementor-widget elementor-widget-counter\" data-id=\"c025bff\" data-element_type=\"widget\" data-widget_type=\"counter.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-counter\">\n\t\t\t<div class=\"elementor-counter-title\">Graf GLP-1<\/div>\t\t\t<div class=\"elementor-counter-number-wrapper\">\n\t\t\t\t<span class=\"elementor-counter-number-prefix\"><\/span>\n\t\t\t\t<span class=\"elementor-counter-number\" data-duration=\"2000\" data-to-value=\"10\" data-from-value=\"0\">0<\/span>\n\t\t\t\t<span class=\"elementor-counter-number-suffix\">kg<\/span>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0749d08 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"0749d08\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7ef5c51 elementor-widget elementor-widget-text-editor\" data-id=\"7ef5c51\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\"><div class=\"elementor-widget-container\"><div class=\"elementor-element elementor-element-10f08cd elementor-widget elementor-widget-text-editor\" data-id=\"10f08cd\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\"><div class=\"elementor-widget-container\"><p>V\u00fdzkum tirzepatidu - <a href=\"https:\/\/tirzepatyd.eu\/cs\/product\/tirzepatid\/\">\u00a0produkty<\/a> je vysoce kvalitn\u00ed, co\u017e potvrzuj\u00ed v\u00fd\u0161e uveden\u00e9 studie. Krom\u011b toho byla jeho v\u00fdkonnost potvrzena v <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34170647\/\">v\u00fdzkum<\/a> klinick\u00fdch studi\u00ed s diabetiky, kter\u00e9 zd\u016fraz\u0148uj\u00ed vysokou \u00fa\u010dinnost GLP 1 + GIP.\u00a0<\/p><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0b37699 e-con-full e-flex e-con e-child\" data-id=\"0b37699\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-aa8db34 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"aa8db34\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Jak\u00e9 \u00fa\u010dinky m\u00e1 GLP\/GIp\/glukagon?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ae4e2f1 elementor-invisible elementor-widget elementor-widget-ucaddon_ue_unfold\" data-id=\"ae4e2f1\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"ucaddon_ue_unfold.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n<!-- start Unfold Content -->\n\n<style>\/* widget: Unfold Content *\/\n\n#uc_ue_unfold_elementor_ae4e2f1{\n opacity: 0;\n transition: opacity .2s;\n}\n\n#uc_ue_unfold_elementor_ae4e2f1.ue-full-opacity{\n opacity: 1;\n}\n\n#uc_ue_unfold_elementor_ae4e2f1 .unfold_wrapper{\n  max-height:100%;\n  width: 100%;\n}\n\n#uc_ue_unfold_elementor_ae4e2f1 .unfold_card{\n  position: relative;\n  overflow:hidden;\n}\n\n#uc_ue_unfold_elementor_ae4e2f1 .uf_overlayuc_ue_unfold_elementor_ae4e2f1{\n    position: absolute;\n    right: 0;\n    bottom: 0;\n    left: 0;\n    z-index: 1;\n    background: -moz-linear-gradient(0deg, #ffffff) 10%, rgba(255, 255, 255, 0) 100%);\n    background: -webkit-linear-gradient(0deg, #ffffff 10%, rgba(255, 255, 255, 0) 100%);\n    background: linear-gradient(0deg, #ffffff 10%, rgba(255, 255, 255, 0) 100%);\n}\n\n#uc_ue_unfold_elementor_ae4e2f1 .ue-btn-wrap{\n        display: flex;   \n    position:relative;\n  z-index:2;\n}\n\n#uc_ue_unfold_elementor_ae4e2f1 #button_uc_ue_unfold_elementor_ae4e2f1{\n    display: flex;\n    justify-content: center;\n    align-items: center;\n    cursor:pointer;\n    transition:0.3s;\n}\n\n#uc_ue_unfold_elementor_ae4e2f1 .ue_unfold_title,\n#uc_ue_unfold_elementor_ae4e2f1 .ue-txt{\n  transition: all .3s ease;\n}\n\n.ue-btn-icon{\n  line-height:1em;\n}\n\n.ue-btn-icon svg{\n  height:1em;\n  width:1em;\n}\n\n#uc_ue_unfold_elementor_ae4e2f1 .unfold_wrapper{\n  overflow:hidden;\n  transition:300ms;\n}\n\n#uf_overlayuc_ue_unfold_elementor_ae4e2f1{\n  transition:300ms;\n}\n\n#uc_ue_unfold_elementor_ae4e2f1 .unfold_wrapper.ue-unfold-active #uf_overlayuc_ue_unfold_elementor_ae4e2f1{\n  height:0px;\n}\n\n#ue-icon-unfolded-uc_ue_unfold_elementor_ae4e2f1{\n  display:none;\n}\n\n#ue-text-unfolded-uc_ue_unfold_elementor_ae4e2f1{\n  display:none;\n}\n\n#uc_ue_unfold_elementor_ae4e2f1  button{\n  outline:none;\n}\n\n<\/style>\n\n\n<div id=\"uc_ue_unfold_elementor_ae4e2f1\" data-scroll-back=\"true\">\n  \n  \n  <div class=\"unfold_card\">\n    <div class=\"unfold_wrapper\" id=\"unfold_wrapper_uc_ue_unfold_elementor_ae4e2f1\">\n      <div class=\"uf_overlayuc_ue_unfold_elementor_ae4e2f1 uf_overlay\" id=\"uf_overlayuc_ue_unfold_elementor_ae4e2f1\"><\/div>\n                          <div class=\"ue-txt\"><div class=\"elementor-element elementor-element-7ef5c51 elementor-widget elementor-widget-text-editor\" data-id=\"7ef5c51\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\"><div class=\"elementor-widget-container\"><div class=\"elementor-element elementor-element-10f08cd elementor-widget elementor-widget-text-editor\" data-id=\"10f08cd\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\"><div class=\"elementor-widget-container\"><div class=\"elementor-element elementor-element-084aebc elementor-widget elementor-widget-text-editor\" data-id=\"084aebc\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\"><div class=\"elementor-widget-container\"><section class=\"elementor-section elementor-top-section elementor-element elementor-element-4e0cfc7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4e0cfc7\" data-element_type=\"section\"><div class=\"elementor-container elementor-column-gap-default\"><div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-efa4c37\" data-id=\"efa4c37\" data-element_type=\"column\"><div class=\"elementor-widget-wrap elementor-element-populated\"><div class=\"elementor-element elementor-element-d97df69 elementor-widget elementor-widget-text-editor\" data-id=\"d97df69\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\"><div class=\"elementor-widget-container\"><p data-start=\"132\" data-end=\"722\">Nejnov\u011bj\u0161\u00ed<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9268041\/\"> v\u00fdzkum<\/a> potvrzuj\u00ed, \u017ee nov\u00fd p\u0159\u00edpravek, schv\u00e1len\u00fd americk\u00fdm \u00da\u0159adem pro kontrolu potravin a l\u00e9\u010div (FDA), m\u016f\u017ee v\u00fdznamn\u011b pomoci lidem s nadv\u00e1hou nebo obezitou. P\u0159i pravideln\u00e9m u\u017e\u00edv\u00e1n\u00ed tohoto peptidu maj\u00ed zdrav\u00ed jedinci potenci\u00e1l sn\u00ed\u017eit a\u017e \u010dtvrtinu sv\u00e9 p\u016fvodn\u00ed t\u011blesn\u00e9 hmotnosti. V\u00fdznamn\u00e9 je, \u017ee tyto \u00fa\u010dinky jsou srovnateln\u00e9 s \u00fa\u010dinky dosa\u017een\u00fdmi p\u0159i bariatrick\u00e9 operaci, a p\u0159itom terapie nevy\u017eadovala drastick\u00e9 zm\u011bny v ka\u017edodenn\u00edm \u017eivotn\u00edm stylu pacient\u016f. Lep\u0161\u00ed stravovac\u00ed n\u00e1vyky a fyzick\u00e1 aktivita mohou samoz\u0159ejm\u011b v\u00fdsledky je\u0161t\u011b zlep\u0161it.<\/p><p data-start=\"724\" data-end=\"1172\">V rozs\u00e1hl\u00e9 studii, kter\u00e9 se z\u00fa\u010dastnilo 2 500 lid\u00ed bez diabetu 1. typu, v\u011bdci zjistili pozoruhodn\u00e9 v\u00fdsledky. V\u00edce ne\u017e 60% \u00fa\u010dastn\u00edk\u016f, kte\u0159\u00ed u\u017e\u00edvali d\u00e1vky 5 a\u017e 15 mg po dobu del\u0161\u00ed ne\u017e jeden rok, dok\u00e1zalo sn\u00ed\u017eit svou t\u011blesnou hmotnost minim\u00e1ln\u011b o 20%. U n\u011bkter\u00fdch pacient\u016f \u010dinil \u00fabytek hmotnosti dokonce 22,5-25%, co\u017e v praxi znamenalo \u00fabytek hmotnosti kolem 28 kilogram\u016f. <a href=\"https:\/\/www.mdpi.com\/2673-4168\/5\/2\/26\">V\u00fdsledky<\/a> ukazuj\u00ed, \u017ee tento p\u0159\u00edpravek m\u016f\u017ee b\u00fdt atraktivn\u00ed volbou pro ty, kte\u0159\u00ed se staraj\u00ed o svou postavu a zdrav\u00ed.<\/p><p data-start=\"106\" data-end=\"405\">Thiopeptid je nov\u00fd l\u00e9k, kter\u00fd m\u011bn\u00ed p\u0159\u00edstup k l\u00e9\u010db\u011b diabetu 2. typu a nadv\u00e1hy. Tento inovativn\u00ed peptid p\u016fsob\u00ed na organismus komplexn\u00edm zp\u016fsobem a aktivuje dva kl\u00ed\u010dov\u00e9 st\u0159evn\u00ed hormony - GLP-1 a GIP - zodpov\u011bdn\u00e9 za regulaci hladiny gluk\u00f3zy v krvi i za kontrolu chuti k j\u00eddlu.<\/p><p data-start=\"407\" data-end=\"717\">D\u00edky sv\u00e9 jedine\u010dn\u00e9 chemick\u00e9 struktu\u0159e vyvol\u00e1v\u00e1 tirzepatyd rychl\u00fd pocit sytosti po j\u00eddle a z\u00e1rove\u0148 stabilizuje hladinu cukru v krvi. To usnad\u0148uje jak udr\u017eov\u00e1n\u00ed norm\u00e1ln\u00ed hladiny gluk\u00f3zy, tak sni\u017eov\u00e1n\u00ed hmotnosti, co\u017e z n\u011bj \u010din\u00ed cenn\u00fd n\u00e1stroj v terapii hubnut\u00ed.<\/p><p data-start=\"719\" data-end=\"1085\">Dosavadn\u00ed v\u00fdzkumy ukazuj\u00ed, \u017ee tirzepatyd je z hlediska \u00fa\u010dinnosti lep\u0161\u00ed ne\u017e klasick\u00e1 l\u00e9\u010dba a je vhodn\u00fd k pou\u017eit\u00ed. Je obzvl\u00e1\u0161t\u011b u\u017eite\u010dn\u00e1 pro osoby s nadv\u00e1hou nebo obezitou. Pod\u00e1v\u00e1 se jednou t\u00fddn\u011b a p\u016fsob\u00ed na receptory GLP-1 a GIP, co\u017e vede ke sn\u00ed\u017een\u00ed chuti k j\u00eddlu, zrychlen\u00ed metabolismu a postupn\u00e9mu \u00fabytku hmotnosti.<\/p><p data-start=\"1087\" data-end=\"1344\">Tajemstv\u00ed tirzepatydu spo\u010d\u00edv\u00e1 ve schopnosti napodobovat p\u0159irozen\u00e9 st\u0159evn\u00ed hormony uvol\u0148ovan\u00e9 po j\u00eddle. Zpomaluje vyprazd\u0148ov\u00e1n\u00ed \u017ealudku a zesiluje sign\u00e1ly sytosti vys\u00edlan\u00e9 do hypotalamu, \u010d\u00edm\u017e pom\u00e1h\u00e1 \u00fa\u010dinn\u011b sni\u017eovat mno\u017estv\u00ed zkonzumovan\u00e9 potravy.<\/p><p data-start=\"1346\" data-end=\"1601\">Thirzepatid p\u0159in\u00e1\u0161\u00ed do l\u00e9\u010dby diabetu a probl\u00e9m\u016f s hmotnost\u00ed novou kvalitu a nab\u00edz\u00ed pacient\u016fm \u00fa\u010dinn\u011bj\u0161\u00ed a pohodln\u011bj\u0161\u00ed \u0159e\u0161en\u00ed. Umo\u017e\u0148uje lep\u0161\u00ed kontrolu hladiny cukru, omezen\u00ed chuti k j\u00eddlu a dosa\u017een\u00ed zdrav\u011bj\u0161\u00ed t\u011blesn\u00e9 hmotnosti.<br \/>Zdroj:<br \/><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33325008\/\">\u00daloha tirzepatidu, du\u00e1ln\u00edho agonisty receptor\u016f GIP a GLP-1, v l\u00e9\u010db\u011b diabetu 2. typu: klinick\u00e9 studie SURPASS<\/a><\/p><\/div><\/div><\/div><\/div><\/div><\/section><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\n            <\/div>\n  \n      <div class=\"ue-btn-wrap\" id=\"btn_wrapper btn_wrapper_uc_ue_unfold_elementor_ae4e2f1\"> \n    <a href=\"javascript:void(0)\" role=\"button\" class=\"ubfold_btn\" id=\"button_uc_ue_unfold_elementor_ae4e2f1\">\n              <span class=\"ue-btn-icon\" id=\"ue-icon-folded-uc_ue_unfold_elementor_ae4e2f1\"><i class='fas fa-angle-down'><\/i><\/span>\n        <span class=\"ue-btn-icon\" id=\"ue-icon-unfolded-uc_ue_unfold_elementor_ae4e2f1\"><i class='fas fa-angle-up'><\/i><\/span>\n            <span id=\"ue-text-folded-uc_ue_unfold_elementor_ae4e2f1\">P\u0159e\u010dt\u011bte si v\u00edce<\/span>\n      <span id=\"ue-text-unfolded-uc_ue_unfold_elementor_ae4e2f1\">V\u00edce informac\u00ed<\/span>\n    <\/a>\n  <\/div>\n\t\n  \n  <\/div>\n  <\/div>\n<!-- end Unfold Content -->\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Tirzepatyd &#8211; jak to dzia\u0142a? Peptydowi agoni\u015bci receptor\u00f3w inkretynowych Poni\u017csze zwi\u0105zki to zaawansowane modulatory szlak\u00f3w metabolicznych badane w kontek\u015bcie ich wp\u0142ywu na receptory GLP-1, GIP i glukagonu. W badaniach naukowych zwraca si\u0119 uwag\u0119 na r\u00f3\u017cnice w sile dzia\u0142ania, selektywno\u015bci receptorowej oraz dynamice odpowiedzi metabolicznej. 1. Tirzepatyd Najwa\u017cniejsze efekty obserwowane w badaniach silna aktywacja receptor\u00f3w GLP-1 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":21458,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-11835","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/pages\/11835","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/comments?post=11835"}],"version-history":[{"count":0,"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/pages\/11835\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/media\/21458"}],"wp:attachment":[{"href":"https:\/\/tirzepatyd.eu\/cs\/wp-json\/wp\/v2\/media?parent=11835"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}